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Hoodia Science

The Science behind Hoodia

There is growing evidence that Hoodia works to supress the appetite.  To start, for thousands of years the Bushmen of South Africa having been eating Hoodia to fight off hunger during their long hunting trips.  

Phytopharm reports clinical studies with Hoodia P57

Phytopharm completed a double-blind, placebo-controlled clinical study in overweight, but otherwise healthy volunteers using Hoodia P57 extract from the Hoodia plant.  Participants were split into two groups, one received the P57 and the other received a placebo. Each group was told to continue their normal diet and exercise. Phytopharm reported results of the study as follows: When comparing the P57 group to the Placebo group: The P57 group had a statistically significant reduction in caloric intake

The P57 group had a statistically significant reduction in body fat

The P57 had no adverse side effects

On average the P57 group ate about 1,000 calories a day less than those in the control group. These are impressive results.  See references below.

Brown University Medical School Research on Hoodia effects with Rats

Researchers at Brown University Medical School performed studies in 2004. In these studies "Zucker Rats" were fed Hoodia. Zucker Rats are special rats that are bred to be obese and diabetic. Amazingly Zucker Rats that were fed Hoodia lost weight and even saw some reversal of their diabetes. Anything that can stop a rat from eating is very significant! (References Below)


  • Van Heerden FR, Vleggaar R, Horak RM, Learmonth RA, Maharaj V, Whittal RD. Pharmaceutical compositions having appetite suppression activity. United States Patent 6,376,657, issued April 23, 2002.
  • Tulp OL, Harbi NA, Mihalov J, DerMarderosian A. Effect of Hoodia plant on food intake and body weight in lean and obese LA/Ntul//-cp rats. FASEB J 2001 Mar 7;15(4):A404.
  • Tulp OL, Harbi NA, DerMarderosian A. Effect of Hoodia plant on weight loss in congenic obese LA/Ntul//-cp rats. FASEB J 2002 Mar 20;16(4):
  • Habeck M. A succulent cure to end obesity. Drug Discovery Today, March 2002, pp 280-1.

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    Hoodia 60 Minutes Report


           Courtesy of  CBS 60 Minutes

    “It's very different from diet stimulants like Ephedra and Phenfen that are now banned because of dangerous side effects. Hoodia doesn't stimulate at all. Scientists say it fools the brain by making you think you’re full, even if you've eaten just a morsel. 60 Minutes Correspondent Lesley Stahl reports.

    So how did it work?  Stahl says she had no after effects – no funny taste in her mouth, no queasy stomach, and no racing heart. She also wasn't hungry all day, even when she would normally have a pang around mealtime. And, she also had no desire to eat or drink the entire day. "I'd have to say it did work," says Stahl”.

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